The purpose of this study was to evaluate the efficacy of diltiazem to prevent sympathetic stimulation during laryngoscopy and endotracheal intubation. This study on the hemodynamic responses to laryngoscopy and endotracheal intubation was
investigated
in 60 surgical patients who received diltiazem 0.2 mg/Kg, diltiazem 0.1mg/Kg and normal saline injection 2 minutes before the laryngoscopy.
The indeces of cardiovascular responses were mean arterial pressure(MAP), heart rate(HR), rate pressure product(RPP) and mean arterial pressure/heart rate(MAP/HR). The indeces were measured at rest, after diltiazem injection, after induction,
immediately after intubation and 1, 2, 3, 5 and 10 minutes after intubation.
@ES The results were as follows
@EN 1) The increses of Mat, RPP and MAP/HR were significantly decreased in diltiazem 0.2mg/Kg group. mg/Kg.
2) There were not decreased cardiovascular response during endotracheal intubation in diltiazem 0.1mg/Kg.
As a result, it seems to us that single bolus diltiazem 0.2mg/Kg induces safe anesthetic induction because lower blood pressure elevation decrease requirement of myocardial oxygen consumption and prevent myocardial ischemia.
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